ATIVAN (LORAZEPAM)

Ativan is a famous drug from the group of benzodiazepine derivatives, which are broadly used for the therapy of a wide spectrum of psychological well being issues from sleeping issues to epileptic seizures. According to the directions to be used, Ativan also has a chilled and relaxing impact.

The drug is relevant for neurosis and anxiousness states accompanied by somatic issues, insomnia and panic attacks. It also has an anticonvulsant and muscle relaxant effect.

PHARMACODYNAMICS AND PHARMACOKINETICS

Pharmachologic impact of Lorazepam is due to its similarity with gamma-aminobutyric acid (GABA). Lorazepam belongs to the category of benzodiazepine derivatives and impacts the CNS buildings, answerable for the regulation of emotional activity (these are limbic system and hypothalamus). The drug provides the move of chlorine into the excited neuron, which in turn stabilizes neuron.

  • anxiolytic
  • sleeping drug
  • anticonvulsant
  • muscle relaxant

Active substance is well absorbed from the digestive tract, reaching its most concentration in the patient’s blood 2 hours later.

INDICATIONS AND CONTRAINDICATIONS

Ativan is extensively used in the fashionable medicine for the therapy of such states and mental sicknesses:

  • psychosis
  • various phobias
  • psychosomatic disorders
  • epilepsy
  • panic attacks
  • obsessive-compulsive syndrome
  • mental disorders related to injuries
  • behavioral disorders
  • sleep disorders
  • headache brought on by increased emotional stress and tension
  • nervousness and anxiety
  • consequences of the shock experienced
  • sickness and vomiting, triggered by a course of chemotherapy

Also, Ativan can be utilized as a part of combination therapy during the remedy of chronic alcohol habit. Sometimes, it is prescribed in combination with analgesic medicines to prepare the sufferers for operative or diagnostic interventions.

Ativan is utilized in medication to eliminate the signs of mental ailments:

  • nervousness
  • increased anxiety
  • tremor
  • insomnia
  • psychosis
  • alcohol delirium
  • cramps
  • paralysis
  • athetosis

Ativan is a strong substance; therefore, it is strictly forbidden to the patients, which have the following concomitant diseases and situations:

  • hypersensitivity to the lively substance or auxiliary components
  • intolerance to other medicine with a similar mechanism of action
  • myasthenia
  • glaucoma
  • intoxication with substances depressing the central nervous system
  • breathing problems
  • liver failure
  • apnea syndrome
  • depression
  • addiction to medicine, nicotine and alcohol (except withdrawal syndrome)
  • alcohol intoxication
  • acute renal failure

The use of Ativan is strictly forbidden to pregnant and breastfeeding women. If the use of Lorazepam is critical for the mother’s well being, she ought to cease breastfeeding for the time of remedy with this drugs. Also, this treatment is forbidden to the minor patients. Elderly patients should take Lorazepam with nice caution and intently monitor the body’s response to the drug.

The use of Ativan can affect the patient’s reaction price. Therefore, during the treatment, you need to chorus from driving and managing other complicated mechanisms and restrict the work requiring caution.

DOSAGE

According to the instructions for use, you should start the remedy with Ativan with the lowest efficient dose, and the course should not be long. With a big dosage and lengthy course, such substances can make the patient addicted. In case of abrupt withdrawal of Ativan, likelihood is that the affected person might expertise withdrawal or rebound syndrome; therefore, it’s essential to cease the course by steadily decreasing the drug dose.

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